The Bonacini cirrhosis discriminant score (CDS) combines the ALT:AST ratio with the platelet count and INR into a discriminant function with possible total values between 0 and 11; higher values increase the likelihood of cirrhosis.
A Bonacini CDS higher than 7 was the most frequently studied threshold (LR, 9.4; 95% CI, 2.6-37). A Bonacini CDS of less than 3 makes cirrhosis less likely (negative LR, 0.30; 95% CI, 0.18-0.50).